Explore the full archive of 60 days of bioenergetic trivia. Practice questions on cellular respiration, metabolism, thyroid function, hormones, and Ray Peat research.
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Day 1
What lowers cortisol? · Which substances, foods, or practices reduce serotonin levels or block serotonin's effects in the body? · What supports healthy thyroid function? · What substances, foods, or practices reduce endotoxin (LPS) absorption or blunt its harmful effects? · What raises the metabolic rate?
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Day 2
What substances, foods, breathing practices, or conditions increase carbon dioxide (CO2) levels in the body? · What substances, foods, or dietary practices protect against the harmful effects of PUFA? · Which substances, foods, or practices improve insulin sensitivity in the body? · What improves sleep quality? · Which substances, foods, or compounds are known or discussed to have anti-cancer or tumor-suppressing effects?
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Day 3
What substances, foods, or practices oppose estrogen's effects in the body? · What substances, foods, or practices are discussed as slowing aging or supporting longevity? · What substances, foods, or practices support heart and cardiovascular health? · What substances, foods, or practices help lower excess iron in the body? · Which light exposures or environmental factors are discussed as beneficial for health?
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Day 4
What substances, foods, or practices help lower lactic acid levels or counter the harmful effects of excess lactate in the body? · What substances, foods, or practices support healthy mitochondrial function — oxidative respiration and membrane integrity? · What substances, foods, or practices shift the body's fuel use from fat oxidation toward glucose (carbohydrate) oxidation? · What substances, foods, practices, or conditions support adaptation to high altitude? · What substances, foods, or practices reduce muscular fatigue or support muscle energy during physical exertion?
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Day 5
What substances, toxins, or conditions impair or damage mitochondrial function? · What health problems are linked to chronic overbreathing (hyperventilation)? · What substances, foods, or practices raise NAD+ levels in the body? · What substances, dietary factors, or conditions suppress the metabolic rate? · What substances act as mitochondrial uncouplers — compounds that dissipate the mitochondrial proton gradient, releasing energy as heat?
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Day 6
What substances, foods, or practices promote cellular differentiation — helping cells mature out of the de-differentiated, glycolytic state toward oxidative metabolism? · What protective or beneficial effects does carbon dioxide (CO2) have in the body? · What are signs or symptoms of impaired mitochondrial function? · What substances, practices, or physiological factors improve the delivery of oxygen from the blood to the body's tissues? · What substances, foods, or practices support healthy methylation in the body?
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Day 7
What are signs or symptoms of excess estrogen activity (estrogen dominance) in the body? · What are common signs and symptoms of hypothyroidism (low thyroid function)? · What health conditions or problems is progesterone discussed as helping with? · What substances, foods, or conditions suppress thyroid function? · What supports the conversion of T4 (thyroxine) into T3, the active thyroid hormone, rather than into reverse T3?
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Day 8
Which substances inhibit aromatase, the enzyme that converts androgens such as testosterone into estrogen? · What raises progesterone levels or supports the body's own production of progesterone? · What is DHT (dihydrotestosterone) discussed as protecting against or helping with? · What health conditions, body functions, or processes are pregnenolone and DHEA said to support, protect, or help with? · What diseases or conditions is healthy thyroid function discussed as protecting against?
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Day 9
What substances, foods, or practices ease menopausal symptoms such as hot flashes, night sweats, or insomnia, or support the body's energy and hormonal balance through the menopause transition? · What substances, foods, or practices ease premenstrual symptoms or menstrual cramps? · What substances, foods, or practices support the body's clearance and detoxification of estrogen — such as liver glucuronidation, bile flow, and gut elimination — so that estrogen is excreted rather than recycled and reabsorbed? · What raises testosterone or supports healthy androgen levels? · What hormonal factors or substances support hair growth or counteract hair loss?
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Day 10
Which conditions or diseases are discussed as being driven or worsened by excess serotonin? · What substances, foods, or practices lower prolactin levels? · What substances, foods, or practices lower histamine or block its effects? · What substances, foods, or practices raise cortisol levels? · What substances, foods, or practices support dopamine function?
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Day 11
What substances or practices reduce excess nitric oxide? · Which conditions are discussed as being driven or worsened by excess cortisol? · What factors are discussed as causing or contributing to insomnia (difficulty falling or staying asleep)? · What substances, foods, or practices lower adrenaline or blunt the adrenaline stress response? · What harms or adverse effects are attributed to SSRI antidepressants?
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Day 12
What substances, foods, or practices raise prolactin levels? · What substances, foods, or practices raise adrenaline levels? · What substances, foods, or practices raise histamine levels? · What substances, foods, or practices raise nitric oxide levels? · What substances, foods, or practices lower dopamine or block its effects?
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Day 13
What conditions or diseases are linked to excess PUFA (polyunsaturated fatty acid) consumption? · What causes or contributes to insulin resistance? · What substances, foods, or practices are discussed as supporting fat loss? · What foods raise blood sugar most rapidly? · Which cooking oils and dietary fats are highest in PUFA (polyunsaturated fatty acids)?
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Day 14
What foods are rich in saturated fats regarded as metabolically safe? · What factors are discussed as increasing the risk of diabetes? · What factors are discussed as causing or contributing to obesity? · What substances, foods, or practices support healthy liver glycogen storage? · What harms of ketogenic or very-low-carbohydrate diets are discussed?
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Day 15
Which hormones, substances, foods, drugs, or physiological conditions raise free fatty acid levels in the blood? · What foods and sweeteners are highest in fructose? · What factors affect how the body responds to dietary carbohydrates? · What foods are highest in starch? · What impairs the body's ability to burn glucose for energy?
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Day 16
What factors, substances, or exposures are discussed as promoting or causing cancer? · What factors, substances, or conditions are discussed as accelerating aging? · What substances, foods, or interventions are discussed as countering cancer cachexia (muscle wasting)? · What helps reduce or prevent lipofuscin (age pigment) accumulation? · What substances or interventions are discussed as blocking metastasis or tumor angiogenesis?
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Day 17
What substances or interventions are discussed as promoting the re-differentiation of cancer cells toward normal cells? · Which substances, foods, or practices help prevent or reverse pathological soft-tissue calcification (e.g., vascular calcification, calciphylaxis, kidney stones, calcific deposits in soft tissues)? · What substances, foods, or practices are discussed as supporting tissue regeneration or stem cell function? · What substances or factors are discussed as protective against prostate cancer? · What helps prevent or reverse fibrosis and collagen cross-linking?
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Day 18
What substances or factors are discussed as protective against liver cancer? · What helps prevent or reverse premature hair graying? · What substances or factors are discussed as protective against breast cancer? · What substances, foods, or practices help counter phosphate toxicity or excess dietary phosphate? · What substances, foods, or practices are discussed as lowering growth hormone or opposing its effects?
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Day 19
What increases the risk of developing Alzheimer's disease? · What strengthens the intestinal barrier or reduces gut permeability ('leaky gut')? · What reduces anxiety or calms an anxious nervous system? Name substances, foods, or practices that ease anxiety. · What supports the liver's ability to detoxify estrogen, serotonin, endotoxin, and other toxins? · Which substances, foods, hormones, or practices support memory and cognitive function?
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Day 20
What reduces inflammation in the body (substances, foods, or practices)? · What can trigger a migraine or severe headache? · What promotes healthy gut flora or helps correct intestinal bacterial overgrowth (SIBO)? · What increases endotoxin (LPS) production in the gut or its absorption into the bloodstream? · What improves bowel transit or relieves constipation?
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Day 21
What substances, foods, nutrients, or practices support dopamine production and dopaminergic signaling? · What helps lower excess iron, reduce tissue iron accumulation, or prevent iron toxicity? · What supports healthy stomach acid (gastric acid / HCl) production? · What damages dopamine-producing neurons or impairs dopamine function? · What substances absorb, bind, or help clear toxins and irritants from the digestive tract?
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Day 22
What substances, foods, or practices reduce blood clotting or blood viscosity? · Which substances, foods, or practices lower blood pressure (hypertension)? · What does getting enough salt (sodium) support in the body? · Which substances, foods, or practices help remove heavy metals (such as lead, mercury, cadmium, or aluminum) from the body — for example, by chelating them or promoting their excretion? · What substances, foods, or practices help prevent or dissolve kidney and gallbladder stones?
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Day 23
What drives or contributes to atherosclerosis — the buildup of plaque in the arteries? · Which substances, foods, or practices reduce edema (swelling caused by fluid retention in tissues)? · What substances, foods, or practices raise cholesterol levels in the body? · What are the signs or symptoms of copper deficiency? · What causes anemia?
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Day 24
What causes heart arrhythmia (irregular heartbeat)? · What are the signs and symptoms of magnesium deficiency? · What substances, nutrients, or practices support bone density and help prevent osteoporosis? · What harmful effects or health problems are attributed to fluoride exposure? · What substances, foods, or conditions increase blood clotting or promote clot formation in the body?
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Day 25
Which conditions or health problems is vitamin D discussed as helping with or protecting against? · What vitamins, supplements, or compounds are discussed as supporting brain health and protecting against neurodegeneration? · What substances, foods, or practices are discussed as helping with gout or lowering uric acid levels? · What health benefits are attributed to heat exposure practices such as saunas, hot baths, steam rooms, or jacuzzis? · Which pharmaceutical drugs are discussed as harmful or damaging to health?
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Day 26
Which conditions, diseases, or health problems is aspirin (salicylates) discussed as helping with? · What substances, vitamins, or compounds are discussed as protecting the liver or helping with liver problems? · Which substances, vitamins, or drugs are discussed as helping with depression or improving mood? · What substances are discussed as having antimicrobial, antifungal, or antiparasitic effects? · What health problems or conditions is methylene blue discussed as helping with?
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Day 27
What substances are discussed as antioxidants or as protecting against oxidative damage? · What substances, vitamins, or drugs are discussed as relieving pain? · Which vitamins, supplements, drugs, or compounds are discussed as supporting gut health or helping with digestive problems? · What substances are discussed as helping the body detoxify or eliminate toxins? · What substances, foods, or practices support dental health — strong teeth and healthy gums?
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Day 28
What substances, foods, or practices support liver function and detoxification? · What foods, substances, or practices support healthy digestion and gut function? · What substances, foods, or practices support skin health? · What substances, foods, or practices protect eye health and vision? · What foods, food additives, or contaminants are discussed as harmful to health?
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Day 29
What substances, foods, or practices support fertility and reproductive health? · What substances, foods, or practices support a healthy pregnancy? · What substances, foods, or practices help reduce allergies and hay fever? · What substances, foods, or practices support the body's defenses against infection? · What substances, foods, or practices support hair health and help prevent hair loss?
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Day 30
What kinds of light, radiation, or electromagnetic exposure are discussed as harmful to health? · What substances, foods, or practices support wound healing? · What substances, foods, or practices support joint health and relieve arthritis? · What drinks or beverages are discussed in the bioenergetics literature as beneficial for health? · Which foods are considered especially nutritious or protective in the bioenergetics view of nutrition?
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Day 31
What conditions or diseases are linked to the Warburg effect (aerobic glycolysis)? · What substances, foods, or conditions raise lactate (lactic acid) levels in the body? · What health conditions are CO2 baths, carbogen breathing, or therapeutic hypercapnia discussed as helping with? · What substances, drugs, or conditions deplete NAD+ levels in the body? · What conditions or diseases are linked to chronic low oxygen levels in the blood or tissues?
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Day 32
What health conditions is pyruvate discussed as helping with? · What substances act as mitochondrial oxidants or alternative electron carriers supporting cellular respiration? · What health problems are linked to oxygen toxicity or excess oxygen exposure? · What substances, practices, or conditions lower carbon dioxide (CO2) levels in the body? · What health conditions is baking soda (sodium bicarbonate) discussed as helping with?
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Day 33
What health problems are linked to chronic high-altitude exposure? · What triggers hyperventilation or respiratory alkalosis (excessive loss of CO2)? · What substances or practices protect against oxygen toxicity? · What conditions or diseases involve chronically elevated lactate levels? · What substances, foods, or practices improve the body's tolerance to carbon dioxide (CO2)?
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Day 34
What are common signs and symptoms of hyperthyroidism (overactive thyroid function)? · What harmful effects are attributed to elevated TSH itself, and what criticisms are raised against the conventional TSH reference-range doctrine? · What pregnancy complications or fetal/infant developmental problems are associated with low thyroid function (hypothyroidism) during pregnancy? · How does thyroid function influence bone health, calcium metabolism, and parathyroid hormone (PTH) activity? · What laboratory tests and physical measurements are used to assess thyroid function?
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Day 35
What substances, foods, drugs, or conditions increase estrogen levels or estrogenic activity in the body? · Which diseases or conditions are discussed as being driven, caused, or worsened by excess estrogen activity in the body? · What environmental estrogens, phytoestrogens, mycoestrogens, or so-called "weak" estrogens are discussed as harmful to health or as functionally potent estrogens? · What harms or adverse effects are attributed to hormonal contraceptives (the pill, IUD, implant, injectables) or hormone replacement therapy (estrogen/progestin drugs like Premarin and Prempro)? · Which hormonal, metabolic, or environmental factors are discussed in bioenergetics literature as triggering, worsening, or lowering the threshold for seizures and epileptic episodes?
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Day 36
What substances, conditions, or physiological factors lower progesterone levels or impair progesterone function? · What causes or contributes to excess androgen activity or virilization in women (hirsutism, hair loss, deepening voice, acne)? · What nutrients, substances, or conditions support the body's production of steroid hormones from cholesterol (the cholesterol-to-pregnenolone step and the downstream pathway to DHEA, progesterone, androgens, and cortisol)? · Which substances, foods, drugs, lifestyle factors, or medical conditions lower testosterone levels or impair androgen function in men and women? · What factors are discussed as causing or contributing to polycystic ovary syndrome (PCOS)?
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Day 37
What substances, drugs, or drug combinations are discussed as causing serotonin syndrome — dangerously excessive serotonin activity in the body? · Which foods are highest in tryptophan, the amino acid the body uses to make serotonin? · Which conditions or diseases are discussed as being driven or worsened by excess histamine? · What substances, foods, or practices support healthy endorphin function or the body's natural opioid system? · What are common signs or symptoms of low dopamine activity?
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Day 38
Which conditions or diseases are discussed as being driven or worsened by excess nitric oxide? · What causes or contributes to histamine intolerance — impaired breakdown and clearance of histamine in the body? · Which conditions or symptoms are discussed as being driven or worsened by excess prolactin? · Which conditions or symptoms are discussed as being driven or worsened by chronically elevated adrenaline? · What substances, foods, or practices support healthy autonomic balance — calming sympathetic overdrive and supporting parasympathetic (vagal) tone?
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Day 39
What substances, habits, or conditions disrupt the body's healthy daily cortisol rhythm — high in the morning, low at night? · What substances, foods, or practices raise DHEA levels or support the body's own DHEA production? · What biological functions or effects is prolactin discussed as having in the body? · What are the acute physiological effects of adrenaline (epinephrine) release during the fight-or-flight response? · What evidence or arguments are discussed against the idea that depression is caused by low serotonin?
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Day 40
Which enzymes, hormones, or physiological processes are impaired or inhibited by PUFA (polyunsaturated fatty acids)? · What harmful effects or health risks are attributed to taking fish oil supplements — including harms from rancidity and oxidation of the oils in the capsules as well as the physiological effects of concentrated PUFA dosing? · What developmental harms or long-term health problems in children and offspring are attributed to high PUFA (polyunsaturated fatty acid) exposure during pregnancy — through the mother's intake — or in early childhood, such as tendencies toward alcoholism, estrogenism, diabetes, infertility, or related developmental effects? · What harmful effects on the liver are attributed to PUFA (polyunsaturated fatty acids) or their metabolites — for example, liver fibrosis driven by lipid peroxidation products, impaired glucuronidation and clearance of estrogen, fatty liver, cholestasis, or impaired liver detoxification? · What everyday signs or symptoms of the body are discussed as indicating excessive PUFA (polyunsaturated fatty acid) consumption — for example, signs affecting the skin, hair, nails, wound healing, or susceptibility to infections — rather than named diseases or conditions?
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Day 41
What complications or forms of tissue damage are attributed to diabetes — for example, retinopathy, neuropathy, nephropathy, vascular calcification, capillary leakage, cataracts, or foot ulcers? · What harms or adverse effects are attributed to intermittent fasting or prolonged fasting (skipped meals, time-restricted eating windows, or multi-day fasts) — as distinct from the harms of ketogenic or very-low-carbohydrate diets? · What metabolic advantages of fructose or sucrose over starch are discussed — for example, bypassing the free-fatty-acid block on glucose metabolism, faster liver glycogen replenishment, lower insulin response, support for thyroid function, or carbon dioxide production? · What substances, foods, or practices lower blood sugar (glucose) levels in the body? · What harmful effects or health problems are discussed as being caused or worsened by high-starch diets (diets rich in starch-heavy foods such as grains, potatoes, legumes, and cereals)?
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Day 42
What are the early warning signs or symptoms of developing diabetes — such as frequent urination, excessive thirst, fatigue, slow wound healing, or darkened skin patches? · What harmful effects or health problems are discussed as being caused or worsened by chronically elevated insulin levels (hyperinsulinemia) — for example, increased fat storage, blocked lipolysis, sodium and fluid retention, arterial damage, or promotion of abnormal cell proliferation? · What kinds of damage to proteins and tissues in the body are attributed to glycation — sugar molecules bonding to proteins, lipids, and other structures (forming advanced glycation end products, or AGEs)? · What harmful effects on the brain — such as excitotoxicity, seizures, impaired learning, depression, anxiety, or Alzheimer's — are attributed to PUFA (polyunsaturated fatty acids)? · What factors OTHER than food and drink raise blood sugar (glucose) levels — hormones, stress responses, sleep disturbances, illness, medications, habits, environmental exposures, and physiological states that increase blood glucose?
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Day 43
What factors are discussed as triggering cancer recurrence or re-awakening dormant cancer cells? · What prenatal or early-life exposures are discussed as increasing cancer susceptibility later in life? · What criticisms or counter-evidence are raised against the somatic mutation theory of cancer? · What factors are discussed as inflating cancer statistics or driving overdiagnosis? · What is discussed about the link between blood clotting, fibrin, and cancer growth or spread?
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Day 44
What factors are discussed as causing or accelerating lipofuscin (age pigment) accumulation? · What substances, foods, or conditions are discussed as causing or accelerating pathological soft-tissue calcification? · What are discussed as measurable biomarkers or signs of biological aging? · What factors are discussed as causing age-related muscle loss (sarcopenia)? · What is discussed about iron's role in promoting infections?
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Day 45
What substances, foods, or practices are discussed as protecting against radiation damage? · What factors are discussed as promoting fibrosis or collagen cross-linking? · What factors are discussed as causing premature hair graying? · What factors are discussed as impairing tissue regeneration or stem cell function? · What foods, substances, or factors are discussed as contributing to phosphate overload or excess phosphate burden?
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Day 46
What factors are discussed as increasing the risk of Parkinson's disease? · What factors are discussed as causing or contributing to depression? · What factors are discussed as contributing to autism? · What causes nightmares or disturbing dreams? · What causes or contributes to tinnitus (ringing in the ears)?
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Day 47
What substances, exposures, or conditions are discussed as damaging or toxic to the nervous system? · What factors are discussed as contributing to schizophrenia? · What causes or contributes to GERD (acid reflux / gastroesophageal reflux disease)? · What causes or contributes to candida or yeast overgrowth in the body? · What impairs immune function or contributes to immunodeficiency?
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Day 48
What causes or contributes to autoimmune conditions? · What causes or worsens inflammatory bowel disease (Crohn's disease or ulcerative colitis)? · What causes or contributes to SIBO (small intestinal bacterial overgrowth)? · What causes or contributes to shock (acute circulatory collapse)? · What causes or drives inflammation in the intestines / gut?
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Day 49
What factors are discussed as causing or contributing to heart failure, including the failing heart's energy deficit and its shift away from glucose oxidation? · What health conditions, body functions, or processes is cholesterol discussed as protecting against or supporting — for example, as a precursor to steroid hormones, as an antioxidant, or in brain function? · What substances, deficiencies, or conditions cause or contribute to increased capillary permeability — abnormal leakiness of the walls of small blood vessels? · What substances, dietary factors, deficiencies, or conditions are discussed as causing or contributing to high blood pressure (hypertension)? · What harmful effects of prolonged endurance exercise (such as marathon running) are discussed?
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Day 50
What substances, foods, deficiencies, drugs, or conditions raise parathyroid hormone (PTH) levels in the blood? · What are the signs or symptoms of iron overload — excessive iron accumulation in the body? · What health conditions, body functions, or processes is copper discussed as supporting, protecting, or helping with? · What health conditions, body functions, or processes is zinc discussed as supporting, protecting, or helping with? · What substances, drugs, dietary factors, or conditions deplete magnesium or lower magnesium levels in the body?
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Day 51
What health conditions, body functions, or processes is iodine — including iodine-rich foods, Lugol’s solution, or potassium iodide — discussed as supporting, protecting, or helping with? · What conditions, disorders, or bodily functions is lithium — including lithium salts, lithium orotate, or trace lithium in water — discussed as supporting, protecting, or helping with? · What health conditions, body functions, or processes is taurine discussed as supporting, protecting, or helping with? · What health conditions is vitamin E discussed as helping with or protecting against? · What substances, foods, or practices are recognized as supporting healthy cellular hydration — the structured, gel-like state of water inside cells?
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Day 52
What conditions or body functions are vitamin A (retinol) and carotenes discussed as supporting or protecting? · What is vitamin E (tocopherols) discussed as protecting against or helping with? · What is vitamin K (K1/K2, MK-4) discussed as supporting or protecting against? · What conditions or health problems is niacinamide (vitamin B3) discussed as helping with? · What is vitamin C (ascorbic acid) discussed as helping with or protecting against?
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Day 53
What is caffeine discussed as protecting against or helping with? · What health problems or conditions is cyproheptadine discussed as helping with? · What is baking soda (sodium bicarbonate) discussed as helping with? · What is DMSO (dimethyl sulfoxide) discussed as helping with? · What is lidocaine discussed as helping with?
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Day 54
What is nicotine discussed as protecting against or helping with? · What is cannabis (cannabinoid compounds) discussed as helping with? · What harms or adverse effects are attributed to statin drugs? · What harms or adverse effects of antibiotics are discussed in bioenergetics sources? · What is sulfur (flowers of sulfur) discussed as helping with?
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Day 55
What foods are naturally rich in gelatin, collagen, or glycine? · What foods are richest in bioavailable calcium? · What health benefits are attributed to regular coffee drinking? · What health benefits are attributed to fruit and fruit juice? · Which plant foods are discussed as highest in anti-nutrients or defensive chemicals, such as protease inhibitors, phytoestrogens, or thiaminase?
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Day 56
What health benefits are attributed to chocolate (dark chocolate / cacao)? · What health benefits or medicinal properties are attributed to mushrooms (when well-cooked)? · What health benefits are attributed to eating seafood? · What health benefits are attributed to eating eggs? · What health benefits are attributed to eating organ meats (offal)?
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Day 57
What substances, foods, or practices are discussed as protecting against ionizing radiation damage? · What health benefits are attributed to sunlight exposure? · What factors are discussed as causing or contributing to myopia (nearsightedness)? · What health conditions is red or near-infrared light therapy discussed as helping with? · What health benefits are attributed to sauna, hot baths, or other deliberate heat exposure?
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Day 58
What factors are discussed as causing or contributing to preeclampsia or eclampsia (toxemia of pregnancy)? · What factors are discussed as driving early or precocious puberty? · What factors are discussed as causing or contributing to PCOS (polycystic ovary syndrome) or ovarian cysts? · What substances, foods, or practices are discussed as supporting libido and sexual function? · What factors are discussed as causing male infertility or impairing sperm health?
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Day 59
What factors are discussed as causing or contributing to fatty liver disease? · What factors are discussed as causing or contributing to kidney disease or impaired kidney function? · What factors are discussed as causing or triggering asthma? · What factors are discussed as causing gout or raising uric acid levels? · What factors are discussed as driving severe COVID-19 illness or poor outcomes?
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Day 60
What factors are discussed as causing or worsening acne? · What factors are discussed as causing or worsening cellulite? · What factors are discussed as triggering or driving autoimmune conditions? · What medical screenings, treatments, or interventions are discussed as causing more harm than good? · What factors are discussed as causing tooth decay or gum disease?